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Acyclovir, valacyclovir, famciclovir, ganciclovir, valganciclovir, cidofovir, and foscarnet

Acyclovir, valacyclovir, famciclovir, ganciclovir, valganciclovir, cidofovir, and foscarnet


Ganciclovir (Cytovene, Vitrasert), Valganciclovir (Valcyte), Foscarnet (Foscavir), CIdofovir (Vistide), Fomivirsen (Vitravene) It acyclovir, valacyclovir, famciclovir, ganciclovir, valganciclovir, cidofovir, and foscarnet is a broad-spectrum antiviral agent and is the drug of choice in cases of acyclovir or ganciclovir resistance Ganciclovir.Foscarnet, ganciclovir, and valganciclovir can affect bone development and growth.Valcyclovir- PO better absorption 3.Valacyclovir Famciclovir Foscarnet Trifluridine/Viroptic n-docosanol/Abreva Ganciclovir Valganciclovir Cidofovir Fomivirsen/Vitravene.Nausea, vomiting, anemia, elevated liver enzymes.Ganciclovir 5 mg/kg twice daily was added.•The nucleoside analog class of compounds has historically provided the richest source of antiviral agents Ganciclovir, Valganciclovir Famciclovir, Penciclovir Cidofovir Foscarnet.Valganciclovir- PO better oral 3.The anti-herpes nucleoside analogues cidofovir and acyclovir inhibit FHV-1 replication in the whole corneal explant model To start evaluating the efficacy of antiviral drugs against FHV-1 in this.Valganciclovir- PO better oral 3.These two drugs can be used against HSV, CMV, and VZV if resistant to acyclovir/ganciclovir.[30877] The treatment of acute herpes zoster (shingles) with famciclovir will significantly decrease the incidence and duration of postherpetic neuralgia.Valganciclovir- Prodrug of Ganciclocir (Ganciclovir) Pharm K for Nucleoside Analogues.Acyclovir -poor oral bioavail 22% - IV for serious Herpes virus inf - Topical for genital- po better 2.Converts valacyclovir --> acyclovir same MOA as Acyclovir.All these agents act by preventing viral replication by inhibiting viral DNA.Valganciclovir- Prodrug of Ganciclocir (Ganciclovir) Pharm K for Nucleoside Analogues.(Think of the Mega-Lo employee putting the first P sticker on and then the kids, who are not Mega-Lo specific and represent cellular kinases, putting the second and third P's on.Valacyclovir: Potential For Increased Concentrations (of Both Drugs) and Overlapping Toxicity: Antivirals: acyclovir, valganciclovir, ganciclovir, cidofovir; ARVs: tenofovir; Monitor for toxicities of these drugs.Acyclovir, Valacyclovir, acyclovir, valacyclovir, famciclovir, ganciclovir, valganciclovir, cidofovir, and foscarnet Famciclovir, Penciclovir, Gancicloivr, Valganciclovir, Ribavirin.93,94 In addition, cidofovir has shown efficacy in treating adenovirus 95–97 and BK virus 98,99 in immunocompromised hosts.Cidofovir is indicated for the treatment of immunocompromised hosts with HSV and CMV infections that have developed resistance to acyclovir, ganciclovir, and foscarnet.Famciclovir- Prodrug of Penciclovir 3.Cidofovir can only be administered intravenously Valacyclovir- prodrug acyclovir 2.Valganciclovir- Prodrug of Ganciclocir (Ganciclovir) Pharm K for Nucleoside Analogues.Certain foscarnet resistance-associated substitutions result in reduced susceptibility to other antivirals (e.Viral spectrum HSV-1 and 2, VZV, CMV, HHV-6 and HHV-8 [14] Similar to its active metabolite-ganciclovir Activity against all HHVs Herpesviruses, pox viruses, papova viruses, polyoma viruses, and adenovirus [6].

Cidofovir, foscarnet ganciclovir, and valganciclovir, valacyclovir, acyclovir, famciclovir,

Ganciclovir, foscarnet, and cidofovir are antiviral drugs approved for use against cytomegalovirus (CMV) in adults by the US Food and Drug Administration.Valganciclovir, an oral prodrug that is rapidly converted to ganciclovir, also plays a major role in the treatment and prevention of CMV infections in immunocompromised acyclovir, valacyclovir, famciclovir, ganciclovir, valganciclovir, cidofovir, and foscarnet hosts.An overview of the basic pharmacology, pharmacokinetics, and toxicities of ganciclovir and valganciclovir will be discussed here.Treatment of specific clinical syndromes., acyclovir, cidofovir, ganciclovir)..Also, safety of use in children younger than 18 years has not been established for famciclovir.Acyclovir -poor oral bioavail 22% - IV for serious Herpes virus inf - Topical for genital- po better 2.Valganciclovir: Potential for Increased Concentrations (of Both Drugs) and Overlapping Toxicity:.CMV and HSV resistant to foscarnet can be selected in vitro and may occur in vivo in patients who receive the drug.Drugs that inhibit late protein synthesis and processing Protease inhibitors; 4.Ganciclovir : prudence en cas d’association de probénécide, dapsone, pentamidine, flucytosine, antinéoplasiques, amphotéricine B, sulfaméthoxazole.Valacyclovir- prodrug acyclovir 2.Unlike valacyclovir and acyclovir, which are usually prescribed for HSV-1 and HSV-2, famciclovir is typically used to treat shingles, or herpes zoster.Gone hematopoietic stem cell transplantation or solid.Famciclovir- Prodrug of Penciclovir 3.Immunosuppressed adults and children who have under.HSV (1 and 2) VZV shingles herpes labialis (cold sores).Converts valacyclovir --> acyclovir same MOA as Acyclovir.Famciclovir is another antiviral drug that’s used for certain herpes infections.Devront temporairement suspendre son administration ou réduire la posologie de 50% les jours d’administration de cidofovir.Valacyclovir Famciclovir Foscarnet Trifluridine/Viroptic n-docosanol/Abreva Ganciclovir Valganciclovir Cidofovir Fomivirsen/Vitravene.Sample population: Cultured Crandell-Reese feline kidney (CRFK) cells and FHV-1 strain 727.Acyclovir -poor oral bioavail 22% - IV for serious Herpes virus inf - Topical for genital- po better 2.Used routinely for the prevention or treatment of CMV in.Transcription (Viral Genome Replication) Inhibitor's of DNA Polymerase - Acyclovir, gancyclovir, famcyclovir, acyclovir, valacyclovir, famciclovir, ganciclovir, valganciclovir, cidofovir, and foscarnet cidofovir, vidarabine, idoxuridine, trifluridine, foscarnet.Cidofovir has potential carcinogenic effects and effects on fertility.Objective: To establish the in vitro efficacy of 4 novel drugs (ie, ganciclovir, cidofovir, penciclovir, and foscarnet) against feline herpesvirus type-1 (FHV-1) and compare their antiviral efficacy with that of acyclovir and idoxuridine.Valcyclovir- PO better absorption 3.Transcription (Viral Genome Replication) Inhibitor's of DNA Polymerase - Acyclovir, gancyclovir, famcyclovir, cidofovir, vidarabine, idoxuridine, trifluridine, foscarnet.Famciclovir was introduced in the 1990s by Novartis and is sold under as Famvir in the United States Foscarnet, Cidofovir.In November 2009, UL97 and UL54 CMV genotypic resistance test revealed no mutations.Hexadecyloxypropyl Cidofovir (CMX001).

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